Biomedical Applications

Oxidative stress and metabolic alterations derived from inflammation and tumour growth lead to hypoxia and angiogenesis in cancer and are associated with disease aggressiveness as well as the evolution of drug resistance. The interplay between blood oxygenation, tumour hypoxia and oxidative stress has yet to be fully understood. Furthermore, there are few validated, non-invasive, methods to detect their spatiotemporal distribution and without these tools, the impact of this interplay on tumour biology cannot be studied. To overcome this limitation and help to elucidate the role of oxygen in cancer, we aim to validate and apply novel imaging methods to study oxygen delivery and utilisation in preclinical models and in patients.