We are an international team of physicists, engineers, chemists, and biologists who work at the clinical interface. We develop novel imaging approaches that can be applied to study tumour evolution. Our imaging innovations arise primarily from low cost optics and photonics technologies, applied both in cancer models and in patients. We are particularly interested in developing methods to interrogate cancer metabolism and the tumour microenvironment. Importantly, we place emphasis on biological validation of our imaging biomarkers, connecting our non-invasive imaging signatures with the processes that generate them at the cellular and molecular levels.