The infrastructure of a solid growing tumour is more than just cancer cells; a complex mixture of stromal and immune cells interplay with the extracellular matrix and broader microenvironmental stress, such as hypoxia. Solid tumours require a vascular network to obtain oxygen and nutrients, then to remove metabolic waste. We are interested in understanding the different ways in which tumours evolve their blood supply, particularly in the context of the interplay between blood oxygenation, tumour hypoxia and oxidative stress. which has yet to be fully understood. There are few validated, non-invasive, methods to detect the spatiotemporal distribution of these processes and without such tools, their impact on tumour biology and cancer patient outcomes cannot be studied. To help elucidate this interplay, we develop and apply novel imaging methods to address this unmet need.
You can find out more about our activities in early cancer detection and treatment response monitoring by clicking the links in-line or in the menu to the right of the page.