Optoacoustic tomography (OT) is an emerging clinical imaging modality that provides static images of endogenous haemoglobin concentration and oxygenation. Here, we demonstrate oxygen enhanced (OE)-OT, exploiting an oxygen gas challenge to visualise the spatiotemporal heterogeneity of tumour vascular function.
Spectrally resolved detector arrays are an exciting new technology that allows spectral information to be recorded by conventional CMOS cameras (akin to those found in your smartphone). Here, we show that an SRDA can in fact be used to detect fluorescence signals for biomedical imaging applications.
In this work, we created a bimodal endoscope to reveal the binding of a near infrared fluorescent dye sprayed onto oesophageal tissue for detection of early malignancy.
The characterisation of modal propagation in fibre bundles is performed here to achieve lensless focusing of imaging data. This is a first step towards performing phase retrieval and lensless focusing during clinical endoscopy using a fibre bundle.
We were able to show here for the first time that optoacoustic imaging is able to detect both the vessel regression and normalisation that is commonly observed with anti-angiogenic therapy. This opens the possibility of using optoacoustic imaging to schedule combination therapy with cytotoxic drugs.
Recently, we developed a dedicated instrument for high throughput Raman spectroscopy, accelerating preclinical studies with this technique and hence improving the long-term prospects for clinical translation.
In this study, we demonstrated for the first time that vitamin C could be hyperpolarized and also used as a contrast agent to detect redox state noninvasively in living subjects.