Featured Publications

Oxygen enhanced photoacoustic imaging reveals vascular dynamics in murine models of prostate cancer.

Posted on , Published to PubMed

M R Tomaszewski, I Quiros-Gonzalez, J O'Connor, O Abeyakoon, G Parker, K Williams, F Gilbert and S E Bohndiek (2017) Theranostics. 7 (11) 2900-2915.

Optoacoustic tomography (OT) is an emerging clinical imaging modality that provides static images of endogenous haemoglobin concentration and oxygenation. Here, we demonstrate oxygen enhanced (OE)-OT, exploiting an oxygen gas challenge to visualise the spatiotemporal heterogeneity of tumour vascular function.

Wide field fluorescence hyperspectral imaging (fHSI) for biomedical applications.

Posted on , Published to PubMed

A S N Luthman, S Dumitru, I Quiros-Gonzalez, J Joseph and S E Bohndiek. (2017) J. Biophotonics. 10 (6-7) 840-853.

Spectrally resolved detector arrays are an exciting new technology that allows spectral information to be recorded by conventional CMOS cameras (akin to those found in your smartphone). Here, we show that an SRDA can in fact be used to detect fluorescence signals for biomedical imaging applications.

Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy

Posted on , Published to PubMed

D J Waterhouse, J Joseph, A A Neves, M di Pietro, K M Brindle, R C Fitzgerald and S E Bohndiek (2016) J. Biomed. Opt. 21(8), 084001.

In this work, we created a bimodal endoscope to reveal the binding of a near infrared fluorescent dye sprayed onto oesophageal tissue for detection of early malignancy.

Summary Figure

Single-pixel phase-corrected fiber bundle endomicroscopy with lensless focussing capability.

Posted on , Published to IEEExplore

G S D Gordon, J Joseph, S E Bohndiek and T D Wilkinson (2015) J Lightwave Technol. 33 16 3419-3425.

The characterisation of modal propagation in fibre bundles is performed here to achieve lensless focusing of imaging data. This is a first step towards performing phase retrieval and lensless focusing during clinical endoscopy using a fibre bundle.

Photoacoustic tomography detects early vessel regression and normalization during ovarian tumor response to the anti-angiogenic therapy Trebananib.

Posted on , Published to PubMed

S E Bohndiek, Laura S Sasportas, Steve Machtaler, Jesse V Jokerst, Sharon Hori and Sanjiv S Gambhir (2015) J Nucl Med. Accepted.

We were able to show here for the first time that optoacoustic imaging is able to detect both the vessel regression and normalisation that is commonly observed with anti-angiogenic therapy. This opens the possibility of using optoacoustic imaging to schedule combination therapy with cytotoxic drugs.

Figure 3 - Photoacoustic Images

A small animal Raman instrument for rapid, wide-area, spectroscopic imaging

Posted on , Published to PubMed

S E Bohndiek, A Wagadarikar, C L Zavaleta, D Van De Sompel, E Garai, J V Jokerst, S Yazdanfar and S S Gambhir (2013) Proc Natl Acad Sci USA 110 (30) 12408-12413

Recently, we developed a dedicated instrument for high throughput Raman spectroscopy, accelerating preclinical studies with this technique and hence improving the long-term prospects for clinical translation.


Hyperpolarized [1-13C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a probe for imaging redox status in vivo

Posted on , Published to PubMed

S E Bohndiek, M I Kettunen, D Hu, B W C Kennedy, J Boren, F A Gallagher and K M Brindle (2011) J Am Chem Soc A 133 (30) 11795-11801.

In this study, we demonstrated for the first time that vitamin C could be hyperpolarized and also used as a contrast agent to detect redox state noninvasively in living subjects.

2011_AATOC graphic